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By Pooja Toshniwal PahariaMay 31 2023 In a recent study published in the journal Nature Communications, researchers examined the phenotypic and genetic evolution of clade 2.3.4.4b highly pathogenic avian influenza A viruses following their spread to North America .
About the study In the present study, researchers reported on the rapid evolution of A influenza viruses after their intercontinental spread to North America. Undifferentiated human airway epithelial cells and primary differentiated human airway cultures were used to evaluate replication kinetics. Sera were obtained from 48 individuals aged between 18.0 and 46.0 years to measure influenza virus neuraminidase protein-targeted cross-protective antibodies using enzyme-linked lectin assays . Antiviral susceptibility of clade 2.3.4.
NAm-strain A virus proteins showed no markers related to virulence among mammals, and all were antigenically homogeneous. The additional viruses pathotyped were A/Red-shouldered Hawk/ North Carolina/W22-121/2022 ; A/Fancy Chicken/Newfoundland/FAV-0033/2021 ; A/Bald eagle/North Carolina/W22-140/2022 ; and A/Lesser scaup/Georgia/W22-145E/2022 .
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