Researchers from University College London propose a novel framework linking reduced inflammation and boosted dopamine transmission through exercise to alleviate depressive symptoms.
By Dr. Chinta SidharthanReviewed by Susha Cheriyedath, M.Sc.Jul 18 2024 In a recent study published in the journal Translational Psychiatry , researchers from University College London discussed the possible mechanisms through which depression impacts motivation and its association with inflammation. They also proposed a novel framework for understanding the pathways through which exercise increases interest and motivation and alleviates depressive symptoms.
The response to treatments such as selective serotonin reuptake inhibitors is also low in most patients, possibly due to the mechanistic heterogeneity of the disease. Interest activity symptoms are strongly associated with impaired motivation. Especially in patients with anhedonia, the lack of reward processing leads to a reluctance to exert effort.
Related StoriesA Areas signalling reward , effort and involved in cognitive control , with areas involved in integrating reward and effort outlined in yellow. White text indicates known modulation by physical activity, especially aerobic exercise. Not all anatomical connections are depicted for reasons of clarity. Light shading indicates that the region is situated more laterally than the slice depicted.
Furthermore, studies that have used tasks involving grip force and effort expenditure for rewards to distinguish between physical inability and a lack of motivation have found that patients experiencing apathy or anhedonia are reluctant to exert effort for any reward. Inflammation has also been linked to motivational symptoms of depression. Systemic inflammation and an increase in pro-inflammatory cytokines have been associated with anhedonia, while treatments to lower inflammation have been beneficial in decreasing anhedonia in patients with depression. Furthermore, an increase in inflammation is also associated with reduced dopamine transmission and lower responses to rewards, which exacerbate depression symptoms such as anhedonia.
Exercise Anhedonia Cortex Depression Disability Dopamine Dopaminergic Fatigue Inflammation Interleukin Mental Health Parkinson's Disease Physical Activity Psychiatry Serotonin
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