Novel nanoparticles deliver innovative cancer chemoimmunotherapy NatureNano CellReports
Fluorescence microscopy image showing FuOXP-siRNA nanoparticles effectively taken up by mouse colon cancer cells. Cell nuclei appear as blue circles. Credit: Chen et al., 2022,Li and his team designed snippets of genetic code called short interference RNA , which shuts down production of specific proteins—in this case, Xkr8. After packaging siRNA and FuOXP together into dual-action nanoparticles, the next step was targeting them to tumors.
"Like a ferry carrying people from one side of the river to the other, we wanted to develop a mechanism that allows nanoparticles to cross intact blood vessels without relying on holes," said Li. When injected into mice, about 10% of the nanoparticles made their way to their tumor—a significant improvement over most other nanocarrier platforms. A previous analysis of published research found that, on average, only 0.7% of nanoparticle doses reach their target.
Proposed strategy for how chemotherapy FuOXP can lead to immunosuppression in tumors but a novel immunotherapy that blocks expression of a protein called Xkr8 can reactivate the immune system . The new study found that FuOXP led to increased levels of Xkr8, a protein that redistributes PS to the cell surface, resulting in immunosuppression due to more T regulatory cells and tumor-promoting M2 macrophages.
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