Obesity impairs the brain's response to nutrients, suggests study amsterdamumc
Brain responses to specific nutrients are diminished in individuals with obesity and are not improved after weight loss, according to a study led by Amsterdam UMC and Yale University, published today in"Our findings suggest that long-lasting brain adaptations occur in individuals with obesity, which could affect eating behavior.
"The subjects with obesity also showed reduced responsivity in brain activity upon infusion of nutrients into the stomach. Overall, these findings suggest that sensing of nutrients in the stomach and gut and/or of nutritional signals is reduced in obesity and this might have profound consequences for food intake."
Food intake is dependent on the integration of complex metabolic and neuronal signals between the brain and several organs, including the gut and nutritional signals in the blood. This network triggers sensations of hunger and satiation, regulates food intake as well as the motivation to look for food. While these processes are increasingly better understood in animals, including in the context of metabolic diseases such as obesity, much less is known about what happens in humans.
In order to address this lack of knowledge, Serlie, who is also a professor at Yale, and colleagues from both institutions designed a
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