The results of a study published in MicrobiomeJ indicate that Odoribacter laneus may be a promising probiotic to deplete succinate and improve glucose tolerance and obesity-related inflammation. Read the paper:
]. We used the “optimizeCbModel” function with default parameters and changed the reaction bounds to −10 for limiting reactions, 0 for absent reactions, and 20 mmol/gDW/h) while the others were limiting . We determined the succinate consumption or production rates as well as the species growth rate in both aerobic and anaerobic conditions in each condition for each species.
Twenty mice were used for each sex and bacterial status. All mice were housed individually for measurement of food consumption. Body weight and food were weighed once weekly from the age of 4 to 9 weeks. Mice were then anesthetized with isoflurane and killed by decapitation. Content and mucosa of the small intestine, cecum, and colon were collected, immediately frozen, and stored at −80°C for analyses.
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