Pancreatic cancer is notoriously hard to treat. A new approach uses bacteria to deliver tetanus into cancer cells, which allows the immune system to find and attack the tumours.
Microscope image of a mouse pancreatic tumour – red spots are listeria bacteria delivering tetanus to tumour cells.Pancreatic tumours have been drastically shrunk in mice using a creative new strategy that allows the immune system to find and kill the cancer cells. The same approach may help to treat this notoriously deadly disease in people.. This is because the cancer often spreads widely before symptoms arise and we lack effective treatments..
The bacteria successfully delivered the tetanus to the pancreatic tumours, making them visible to the immune systems of the mice. Immune cells called T-cells then started attacking the tumours. This treatment combination reduced the size of both the original pancreatic tumours and those that had spread to other parts of the body by over 80 per cent. It also improved the average survival time of the mice by 40 per cent compared with untreated mice.
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