Patients with high-risk melanoma had better qualityoflife on pembrolizumab than on standard immunotherapy regimens NEJMEvidence JAMAOnc
Patients with high-risk stage III-IV melanoma who received pembrolizumab after their surgery reported a better quality of life than patients who received the previous standard-of-care treatment with either ipilimumab or high-dose interferon.
Patients on the S1404 study completed standard questionnaires to report on their quality of life at five time points during treatment and at 24 weeks and 48 weeks after they finished treatment. If their cancer recurred, patients were asked to complete one additional quality-of-life assessment at that time.
Primary clinical findings from the S1404 trial were reported in June of 2021, at the annual meeting of the American Society of Clinical Oncology. Those results showed that in patients with stage III or IV melanoma who had undergone surgery to remove their tumors, those treated with pembrolizumab after surgery lived significantly longer without a recurrence of their cancer than those treated with ipilimumab or high-dose interferon.
Senior author Sapna Patel, MD, chair of the SWOG melanoma committee and associate professor of Melanoma Medical Oncology at The University of Texas MD Anderson Cancer Center, compared these quality-of-life findings from S1404 with findings from a recent study of adjuvant pembrolizumab in patients with stage III melanoma—the KEYNOTE 054 study.
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