People respond differently to psychedelicdrugs—genetics could be the reason
receptor's structure and function. So, Bryan Roth and colleagues wanted to explore how variations in the serotonin 5-HTThe researchers used a series of assays to measure the effect that seven different SNPs had on in vitro binding and signaling of the 5-HTserotonin receptor when in the presence of psilocin, LSD, 5-MeO-DMT or mescaline. Their results indicated that some gene variations, even ones at a distance from the, alter the way the receptor interacts with the psychedelic drugs.
For example, the single nucleotide polymorphism Ala230Th had both increased and reduced responses to the drugs tested compared to the original version of the gene, whereas the His452Th mutation showed only reduced effects. Based on their results, the researchers expect that patients with different genetic variations would react differently to psychedelic-assisted treatments.
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