Testing whether a new drug impacts the progression of Parkinson's disease takes years, in part because the disease often advances so slowly. Many Parkinson's patients don't have any worsening of their symptoms over the course of a typical clinical trial, even without treatment.
npj Parkinson's Disease
Parkinson's disease is a progressive disorder of the nervous system and affects about one million people in the United States. The earliest symptoms are often barely noticeable tremors, and over the course of many years the disease progresses, eventually impacting movement, posture, facial expressions, speech and eating, as well as causing pain and dementia.
Overall, 529 patients were found to be"progressors" over the first 12 months of the study, with their symptoms significantly worsening, while 350 were grouped as"non-progressors." Torkamani's group used a machine learning approach to develop a model that could predict, with 77% accuracy, which group patients belonged to.
For now, the model doesn't have clinical value for individual patients, since there are no drugs that have been shown to slow the progression of Parkinson's. However, the researchers hope that being able to choose"progressors" for clinical trials makes it easier and faster to pinpoint these kinds of drugs as the field moves forward.
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