Higher levels of diglycerides and triglycerides adversely associated with glaucoma brighamwomens NatureComms
furthermore, we included only metabolites with good correlations for within-person stability over at least 1 year.
There are other study design issues to consider. The UK Biobank included participants with prevalent glaucoma, which would have been comprised mostly of POAG cases, but may have also included those with other glaucoma types or glaucoma suspects. Furthermore, in the UK Biobank, metabolite levels may have been influenced by glaucoma treatment.
Our study had several strengths. To our knowledge, our study in NHS/NHSII/HPFS is the first study assessing the associations of pre-diagnostic metabolites and POAG risk, with a relatively large sample size of 599 cases and 599 matched controls. Additional strengths include the detailed covariate information and long time between blood draw and diagnosis date and the availability of the UK Biobank data to confirm findings.
Overall, these results provide new insights into the etiology of POAG. Our data implicate dysregulation in lipid metabolism and mitochondrial function in glaucoma etiology and suggest new targets for glaucoma prevention or therapies.We conducted a nested case-control study in the United States-based NHS, NHSII, and HPFS cohorts.
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