Precision nutrition vs. low-fat diet: No significant difference in diabetes management PrecisionNutrition GlycemicControl GlycemicVariability HbA1c Postprandial Glucose Prediabetes Type2Diabetes Diabetes Prevention Glycemic nyulangone
By Dr. Chinta SidharthanMay 30 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in The American Journal of Clinical Nutrition, researchers compare changes in hemoglobin A1c and glycemic variability in prediabetic individuals or those with moderately managed type 2 diabetes to understand the impacts of two calorie-restricted weight loss diets.
However, standard diets with low glycemic load or low carbohydrate content have had mixed or negative results in clinical trials, as they do not consider individual variability in PPGR to the same foods. A personalized diet based on the PNP algorithm was compared to a standardized low-fat diet in this randomized clinical trial called the Personal Diet Study by examining changes in HbA1c and glycemic variability during the intervention period.
Related StoriesThe stool samples were used for microbiome analysis, which was then correlated with data on anthropometrics, health variables, sociodemographic information, and HbA1c to determine the personalized meal scores. The primary measured outcomes included mean amplitude of glycemic excursions and HbA1c values, while secondary outcomes included mean continuous glucose monitor readings, continuous overall net glycemic action , coefficient of variation, and standard deviation.
In addition to the coefficient of variation for the continuous glucose monitor glucose measures, other measures of glycemic variation and HbA1c decreased for both groups. Between the two groups, no differences were observed, even when the analysis was stratified by sex.
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