New study finds the placenta, not just the brain, plays a central role in genetic risk of schizophrenia NatureComms
), suggesting that pleiotropic effects in the two organs may contribute to trajectories of risk for the disorder, also through tissue-specific mechanisms. Among the 199 placental genes also associated with schizophrenia in prenatal cortex, 142 show opposite sign of association in placenta and brain.
The placental transcriptome is highly and selectively relevant for schizophrenia, in comparison with other developmental disorders and traits Part of the genomic component of schizophrenia risk is shared with other complex disorders and traits, some of which also have developmental origins. We asked whether placental genes associated with schizophrenia would show relationships with other disorders and traits. We, therefore, performed analogous placental g-TWASs and tx-TWAS on other complex disorders and traits with a developmental component.
We detected genes and transcripts with a TWAS-significant association in placenta with each of these conditions, with the exception of insomnia (Table
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