Novel imagingagent allows for earlier detection of progressive pulmonaryfibrosis
Invariably fatal and with a particularly fast progression, pulmonary fibrosis is currently devoid of curative treatment options. Routine clinical diagnosis relies on breathing tests and visualizing the changes in lung structure by CT, but anatomic information is often not sufficient to identify early signs of progressive PF.
Therefore, novel molecular targets enabling specific diagnosis are investigated, in particular for molecular imaging techniques.Cu-radiolabeled platelet glycoprotein VI fusion protein targeting extracellular matrix fibers as a PET tracer to observe longitudinal ECM remodeling in a bleomycin-induced PF mouse model.Cu-GPVI-Fc showed significant uptake in fibrotic lungs, matching histology results.
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