People are advised to only travel by train if necessary, with just a fifth of services running.
Some commuters were able to work from home on the first two strike days, but there are several big events in London over the weekend, including a sell-out Rolling Stones concert in Hyde Park and Ed Sheeran at Wembley.
Services across England, Wales and Scotland are primarily restricted to main lines, and those are only open between 07:30 and 18:30 BST. The Rail, Maritime and Transport union is looking for a pay rise of at least 7% and assurances of no compulsory redundancies. Network Rail said it would consider a pay rise above 3%, but only if the union agreed to modernise working practices.
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