Research explores complex relationship between cholesterol and breast cancer risk Cholesterol Cancer RiskFactors Research HealthImplications BreastCancer CholesterolLevels ElsevierConnect :
By Dr. Sanchari Sinha Dutta, Ph.D.Jun 15 2023Reviewed by Benedette Cuffari, M.Sc. In a review article published in The Journal of Steroid Biochemistry and Molecular Biology, scientists discuss the role of cholesterol and its metabolites in breast cancer.
The role of cholesterol in breast cancer remains poorly understood, with many studies reporting contradictory results. Whereas some studies have established a positive association between blood cholesterol levels and breast cancer risk, others studies have found an inverse relationship between total cholesterol and high-density lipoprotein -cholesterol levels and breast cancer risk.
Although reduced HDL-cholesterol levels have been found to increase breast cancer risk, increased levels of total cholesterol and low-density lipoprotein -cholesterol are associated with a reduced risk of breast cancer. Cholesterol metabolites Various cholesterol metabolites have been found to influence breast cancer risk. Oxysterol, for example, exhibits tumor-promoting activity, whereas dendrogenin A associated with tumor-suppressing activity. Likewise, 27-hydroxycholesterol, an endogenous oxysterol, increases estrogen receptor- and liver X receptor-dependent tumor growth in mice.
How does cholesterol affect breast cancer risk? Cholesterol has been shown to increase cancer cell proliferation by stimulating AKT phosphorylation. LDL has also been found to stimulate the proliferation and migration of breast cancer cells.
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