Researchers at the Francis Crick Institute have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease infection.
The lung barrier between the body and the air outside is only made up of two layers, one of endothelial cells and one of epithelial cells, because it needs to allow oxygen to enter. But the barrier also has to be kept strong against pollution or viruses and bacteria.
They also found that mice with enhanced AHR activity didn't lose as much weight when infected with flu, and were able to better fight off aWhen AHR was prevented from being expressed in the lung endothelial cells of infected mice, more blood and immune cells were seen in the air spaces, showing greater damage to the barrier.causes a decrease in protective lung AHR activity, but only in mice fed AHR ligands in their diet before the illness.
Andreas Wack, Group Leader of the Immunoregulation Laboratory at the Crick, said,"Until recently, we've mainly looked at barrier protection through the lens of immune cells. Now we've shown that AHR is important for maintaining a strong barrier in the lungs through the endothelial cell layer, which is disrupted during infection.
Jack Major, former Ph.D. student in the Wack lab and now visiting scientist at the Crick and first author, said,"What we've identified is a gut-lung axis—linking diet to protection against lung infection via endothelial cells.
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