A new editorial paper titled 'A macrophage is a macrophage is a macrophage—in metastasis' has been published in Oncotarget.
Macrophages have important roles in the response to infection or injury and can orchestrate the appropriate response after sampling their microenvironment, devouring anything untoward and presenting ingested antigens to T cells to elicit an adaptive immune response. In, they develop from bone marrow-derived precursors and circulating monocytes, which differentiate into macrophages within tissue.
"Apart from their role in clearing challenges to tissue integrity, macrophages have an essential role in growth-related processes such as angiogenesis and vascular remodeling, neural patterning, and ductal growth of developing glands," says Tapmeier. However, their powers can be usurped by tumors, which cannot grow beyond a certain size or metastasis without the help of macrophages. This is crucial, as themight be amenable to treatment—so that patients can live with it—but metastasis is yet untreatable and inevitably becomes incompatible with survival.
"Thus, therapy attempts based on countering macrophages try to target the surface receptors that recruit them to sites of infection, inflammation or growth," says Tapmeier.Oncotarget
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