An international team of scientists has developed a method for simultaneously detecting thousands of lipid molecules that are displayed to T cells in the human immune system.
The study, co-led by D. Branch Moody, MD, of the Division of Rheumatology, Immunity and Inflammation at Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, represents a collaboration among researchers from Oxford, United Kingdom, Melbourne, Australia and Groningen, Netherlands.
Their efforts yielded the first integrated CD1 lipidomic map, which could help guide the investigation and discovery of lipid blockers and antigens for T cells and support the view that lipids normally influence immune responses.
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