Researchers explore viral emissions in a phase 1, open label, first-in-human SARS-CoV-2 experimental infection study LancetMicrobe imperialcollege virology SARSCoV2 COVID19 coronavirus covid
By Bhavana KunkalikarJun 13 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to The Lancet Microbe, researchers explored the release of viral particles into the environment and air after a severe acute respiratory syndrome coronavirus 2 human challenge.
The participants were placed in individual negative pressure rooms. The study involved administering 10 50% tissue culture infectious doses of pre-alpha wild-type SARS-CoV-2 to participants via nasal drops. The participants were kept in quarantine for at least 14 days after being inoculated until they met the criteria for discharge. Daily collection of nasal and throat swabs was conducted. The study also collected air samples from a distance of one meter from the participant's head.
Results The study enrolled 36 participants between 6 March and 8 July 2021. Out of 34 seronegative participants, 18 reported SARS-CoV-2 infection after the challenge. The infected participants experienced mild-to-moderate symptoms and had high viral loads in their nose and throat for a long time after a short incubation period. The air, breath, and rooms of uninfected persons were free of viral contamination.
Consistent levels of human housekeeping gene 18S rRNA were found in daily air specimens from the same individual, suggesting that the amount of expelled airborne particles did not change during infection and that particles detected in the air sample remained stable.
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