SARS-CoV-2 activates NLRP3 inflammasome natureportfolio UQ_News SARSCoV2 COVID19 Inflammasome
By Bhavana KunkalikarNov 7 2022Reviewed by Aimee Molineux In a recent study published in the Molecular Psychiatry journal, researchers assessed the role of severe acute respiratory syndrome coronavirus 2 in the NLR family pyrin domain containing 3 inflammasome activation.
The team infected female K18 human angiotensin-converting enzyme 2 mice with an early clinical isolate of the SARS-CoV-2 Wuhan strain to assess the virus' impact on the brain. Up to 12 days post-infection , body weights, clinical scores, and survival rates were documented. Subsequently, a nanobody that detected divergent SARS-CoV-2 variants, such as the Wu strain, was employed to examine the brains of infected mice with six dpi.
Lab Diagnostics & Automation eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today The team created a low endotoxin S-clamp and a control trimeric fusion protein derived from the Nipah virus. These proteins were verified using sodium dodecyl-sulfate polyacrylamide gel electrophoresis , size exclusion chromatography, and enzyme-linked immunosorbent assay to further understand the mechanism of inflammasome activation by SARS-CoV-2.
Inflammasome activation was induced by SARS-CoV-2 infection in MDMi, as evidenced by cleaved interleukin -1 release in the cells' supernatant after exposure to the Wuhan strain. This supported the inflammasome's activation by correlating with rising levels of cleaved caspase-1. ASC speck formation, a biological indicator of inflammasome activation, supported these findings.
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