Why Do More Women Develop Alzheimer’s Disease? Scientists Think a Gene Is Responsible
, two-thirds of the 6.5 million Americans currently living with the devastating brain disease are women—and this trend is consistent around the world.
The researchers conducted a genome-wide association study for Alzheimer’s in two independent groups using different methods for each. In the first approach, the individuals with Alzheimer’s were all Hutterite women, a group of people who all share a relatively small gene pool due to inbreeding. The second approach, predicated on evidence suggesting a link between Alzheimer’s and breast cancer, analyzed genetic data from a national group of 10,340 women who lacked APOE ε4.
The researchers then further investigated the MGMT gene, using multiple types of molecular data and other Alzheimer’s disease-related traits obtained from human brain tissue. Ultimately, they found that epigenetically regulated gene expression of MGMT is significantly associated with the development of distinctive Alzheimer’s disease proteins, amyloid-β and tau, especially in women.
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