Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut Microbiome Gut CircadianRhythms PNASNews Penn
Study: The microbiome stabilizes circadian rhythms in the gut. Image Credit: Vovantarakan / Shutterstock
In the current study, scientists have explored the interplay between the gut microbiome, time-restricted feeding pattern, and circadian rhythms in the Drosophila gut. Impact of time-restricted feeding on circadian transcriptome The analysis of circadian gene expression was conducted in the study using flies with and without a microbiome. The findings revealed that both time-restricted feeding and microbiome loss significantly impact the gut's circadian transcriptome.
An induction in cycling gene expression was observed under time-restricted feeding conditions. Altered activities of transcription factors were found to be responsible for the global changes in cycling expression. Similar to time-restricted feeding, loss of microbiome was found to influence cycling gene expression.
Functional impact of time-restricted feeding and microbiome Omics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Flies maintained with time-restricted feeding were subjected to different stressors to determine the impact of restricted feeding on health and fitness.
The findings revealed that the microbiome's presence increases circadian clock gene cycling in flies' brains. Overall, it was observed that sterile flies reset more rapidly with shifts in the day-night cycle compared to flies with a microbiome.
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