Our brains are awash with various unsung chemical heroes, making sure the electrical signals traveling all over the place don't get out of control.
A new mouse study has now detailed the function of a pair of proteins vital to maintaining this balance – this could help us better understand a range of neurological disorders from epilepsy toThe two proteins – Rab3-interacting molecule 1 and an enzyme called serine arginine protein kinase 2 – work together to modify the transmission of information across the gaps between nerves called synapses.
Using neurons from specially prepared lab mice, researchers from Germany and Australia have now described in detail the precise chemical interplay between the two proteins, which not only helps us better understand typical brain functioning but could one day provide therapeutic targets for conditions where this process goes awry.
Like any efficient public transport system, this flow of travelers needs guidance on when to wait and when to board. Which is where RIM1 comes in. It's likely more complex animals will have different mechanisms that help fine-tune their own brains, so researchers analyzed the mechanisms of the protein extracted from mouse brains to see just how it operated.
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