A previously unknown type of synapse appears to have been hiding in strange, hair-like appendages that can be found on the surfaces of neurons, new research reveals.
A study in mice suggests that structures called primary cilia play a role in neuronal signaling; specifically, they act as a shortcut for transmitting signals directly into the nucleus to trigger changes to chromatin, the complex that forms chromosomes.
That's at least partially because they are so small that they are hard to make out using traditional imaging techniques, the researchers say. For the second stage of the research, researchers employed a newly developed biosensor in concert with a technique called fluorescence lifetime imaging , to observe the biochemical processes taking place inside the cilia in living mice.
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