Scientists uncover protective role of NAD maintenance in kidneydisease pennmedicine
for kidney disease, according to a discovery by a new study led by researches in the Perelman School of Medicine at the University of Pennsylvania.Metabolic changes related to NAD may offer a new therapeutic target to improve the course of kidney disease.
"We hope that this research can lead to improved care in the future. So when patients have metabolite changes, they can receive treatment before kidney disorders arise," said co-lead investigator Katalin Susztak, MD, Ph.D., a professor of Nephrology and member of the Institute for Diabetes, Obesity, and Metabolism and Kidney Innovation Center at Penn Medicine.
Using unbiased metabolomic studies, the team identified changes in NAD metabolism in both mouse and human kidneys. In the mouse studies, they showed that using a common supplement,or nicotinamide mononucleotide, to boost NAD protected mice from kidney dysfunction by protecting the mitochondria—the powerhouses—of kidney tubule cells.
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