Severe COVID-19 raises alarm for undiagnosed cancer COVID Cancer UndiagnosedCancer SARSCoV2 ICU CancerAfterCOVID HealthResearch PublicHealth MedicalStudy SciReports
By Dr. Chinta SidharthanJun 1 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Scientific Reports, researchers investigated whether the severity of the severe acute respiratory syndrome coronavirus 2 infection was indicative of undiagnosed cancer.
The six factors that increased the morbidity and mortality risk of cancer patients to SARS-CoV-2 infections were age, increased expression of the angiotensin-converting enzyme 2 receptor transmembrane serine protease 2 , immunosuppression due to cancer treatments, as well as a pro-coagulant state and inflammatory responses induced by cancer. Some of these factors could influence the susceptibility to severe SARS-CoV-2 infections in individuals with undiagnosed cancers.
From anonymized data, specific medical algorithms were used to identify pathologies, causes for hospitalization, long-term illness diagnoses, and treatment reimbursements. The study included data on intensive care unit admissions between February 15, 2020, and August 31, 2021, which covered the period between the onset of the COVID-19 pandemic and the end of the fourth wave in France.
Information on sex, age, area of residence, and socio-economic status were determined, and co-variables such as existing comorbidities, COVID-19 vaccination status, treatment with corticosteroids or immunosuppressants, and addictive disorders were analyzed. COVID-19 hospitalization and increased risk of cancer A total of 897 of the 41,302 individuals admitted to the ICU with SARS-CoV-2 infection were diagnosed with cancer during the follow-up months as compared to 10,944 of the 713,670 controls diagnosed with cancer. In fact, individuals who had been admitted to the ICU had a 1.31 times higher risk of a cancer diagnosis than those who did not require hospitalization for SARS-CoV-2 infection.
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