The band will play to 850 people at Sheffield's Leadmill before embarking on a European tour.
"Sheffield is in the very DNA of this band," he said.
"We know there are a lot of small music venues struggling across the UK, so we wanted to give back to what gave to us." Ben Hartley, from the Leadmill, said the show - Def Leppard's first at the venue - would add "another chapter to Sheffield's musical history".
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