Two short-course bedaquiline-containing treatment regimens for rifampicin-resistant TB showed 'robust evidence' for superior efficacy and less ototoxicity compared to a 9-month injectable control regimen, researchers report. MedTwitter
The 6-month regimen included bedaquiline, clofazimine, pyrazinamide, and levofloxacin for 28 weeks, supplemented by high-dose isoniazid withFor both comparisons, the primary outcome was favorable status at 76 weeks, defined as cultures that were negative forAmong 517 participants in the modified intention-to-treat population across the study groups, 62% were men, and 38% were women .
In the secondary comparison, 69% had a favorable outcome in the control group, compared to 91% of those receiving the 6-month regimen. Exploratory analyses comparing both bedaquiline-containing regimens revealed a significantly higher proportion of favorable outcomes among participants receiving the 6-month regimen compared with patients taking the fully oral 9-month regimen . There were no significant differences in the rate of grade 3 or 4 adverse events.
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