Study compares long-term consequences of COVID-19 between patients with rheumatic inflammatory diseases and healthy controls TheLancetRheum amsterdamumc COVID19 coronavirus covid longcovid inflammation inflammatorydisease disease
By Neha MathurJun 8 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in the Lancet Rheumatology, researchers used data from a long-term ongoing prospective cohort study in the Netherlands to compare the characteristics of long-COVID in inflammatory rheumatic diseases patients and healthy controls during the period when the severe acute respiratory syndrome coronavirus 2 Omicron subvariants, BA.1/BA.2 were dominant.
Per recent studies, persistent inflammation and auto-immune reactions after the acute infection phase play a crucial role in the progression of post-COVID. However, all pathophysiological mechanisms underlying this condition also remain unclear. Thus, it is still unknown whether rheumatic disease patients are more susceptible to long-COVID and their clinical phenotype varies from other people.
They used Kaplan-Meier survival analyses to compare the time taken to recover from long-COVID following Omicron infection between patients of two study cohorts during the first 26 weeks after disease onset. Likewise, they presented the variations in the symptomology of post-COVID condition across both cohorts as bar charts.
Results The final analysis set of the study comprised 1974 inflammatory rheumatic disease patients and 733 controls, whose mean age was 59 years. Patients with inflammatory rheumatic disease more frequently suffer from cardiovascular and pulmonary diseases and other health issues like diabetes and obesity.
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