Study: Healthy lifestyle may reduce impact of life-shortening genes

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Study: Healthy lifestyle may reduce impact of life-shortening genes
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A healthy lifestyle may offset the effects of life-shortening genes by more than 60%, suggests an analysis of the findings from several large long term studies, published online in the journal BMJ Evidence Based Medicine.

Apr 29 2024BMJ A healthy lifestyle may offset the effects of life-shortening genes by more than 60%, suggests an analysis of the findings from several large long term studies, published online in the journal BMJ Evidence Based Medicine .

But it's not clear the extent to which a healthy lifestyle might offset genetic predisposition to a shortened lifespan, say the researchers. And a weighted healthy lifestyle score, to include no current smoking, moderate alcohol consumption, regular physical activity, healthy body shape, adequate sleep, and a healthy diet, was categorized into favorable , intermediate , and unfavorable lifestyles, using data from the US NHANES study.Those genetically predisposed to a short lifespan were 21% more likely to die early than those genetically predisposed to a long life, regardless of their lifestyle.

Four factors in particular seemed to make up the optimal lifestyle combination: not smoking; regular physical activity; adequate nightly sleep; and a healthy diet.

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