Study investigates associations between potential endocrine-disrupting chemicals and female fertility Chemicals Endocrine Fertility WomensHealth Endocrinology UniUtrecht HarvardChanSPH karolinskainst tallinntech _SLU VUamsterdam unitartu
Study: Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia. Image Credit: ADragan / Shutterstock
It is imperative to determine how EDCs are associated with biomarkers of female fertility, such as the ovarian sensitivity index . OSI measures ovarian capability by analyzing its response to the exogenous follicle-stimulating hormone stimulation during ART. OSI is closely related to live birth rates because it determines the remaining pool of oocytes and functional aspects of ovaries. Therefore, OSI has been considered a good biomarker of female fertility and a predictor of ART’s success.
Overall, 59 chemicals were detected in the follicular fluid samples, along with three phthalate metabolites, di-2-ethylhexyl phthalate metabolites, six PFAS, and one paraben, in over 90% of the study cohort. Strengths and Limitations One of the key strengths of this study is its methodology. For instance, the analysis of two separate cohorts improved the generalizability of the findings. The authors claimed this study to be the first to investigate the relationship between EDCs and OSI.
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