Study measures the annual prevalence of nontuberculous mycobacterial lung disease in Ontario, Canada CDC_NCEZID mycobacteria lungdisease lung disease canada health
By Neha MathurJun 1 2023Reviewed by Lily Ramsey, LLM In a recent article published in Emerging Infectious Diseases journal, researchers performed a retrospective cross-sectional study in Ontario, Canada, to determine the prevalence of nontuberculous mycobacterial pulmonary disease in 2020 based on screening/testing of pulmonary NTM isolates.
About the study In the present study, researchers used BACTEC MGIT 960 instrument to culture NTM isolates collected by Ontario's public health laboratories. To identify NTM at the subspecies level, they used the following methods:iii) a lab-engineered MAC real-time polymerase chain reaction ; orNext, they categorized NTM-PD isolates into uncertain, standard, and strict based on microbiological criteria. The 'standard' NTM-PD isolates had a 70 to 100% positive predictive value.
Results In 2020, 8,412 of 41,471 pulmonary samples tested for mycobacteriology grew NTM. The NTM-PD prevalence of the standard category in 2020 was almost double the reported cases in 2010 . Even M. intracellulare and M .abscessus caused much lesser standard and strict microbiological disease cases than M. avium, i.e., only 6.4%, 6.3%, and 5.8%, 7.1%, respectively.
Previously, many population-based studies conducted in the United States, Denmark, Croatia, and Spain have demonstrated increases in NTM-PD. Eight such studies even fetched species-level data.
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