Study provides clues on why some bad infections persist uofuhealthcare
"Every kind of stress we exposed the MiaA-deficient strain to seemed to cause problems," said the study's co-first author Matthew Blango, Ph.D, who is now a junior research group leader at the Leibniz Institute for Natural Product Research and Infection Biology in Jena, Germany."So, we really thought that thisBacteria without MiaA did not grow well and did not cause urinary tract infections or sepsis in mice.
Seeing how badly things went when MiaA levels were out of balance, former graduate student Brittany Fleming, Ph.D., the study's co-first author, investigated further. She discovered that knocking out MiaA caused random"frameshifting"—an error where tRNA delivers three-letter genetic codes to be translated into proteins that are off by one letter. For example, a genetic code of"cat cat gta" might read as"atc atg ta…" when frameshifted.
Additional experiments by co-first author and graduate student Alexis Rousek showed that changing levels of MiaA could alter the availability of key metabolites that feed into other important stress response pathways within the bacteria. These findings implicate MiaA as a key player within a web of pathways that can impact pathogen stress resistance.alters MiaA levels within bacteria.
The implications for this research may extend beyond infection control. Humans express a version of MiaA that is linked to certain cancers and metabolic diseases."What we learned about how MiaA works is likely to be relevant to research on cancer and other non-infectious human diseases," Mulvey said.
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