Study reveals factors impacting pertussis antibody half-lives in infants, sheds light on preterm infants' resilience JIDJournal MedUniGraz antibody antibodies halflife halflives preterm infant
By Dr. Chinta SidharthanJun 9 2023Reviewed by Lily Ramsey, LLM In a recent study published in The Journal of Infectious Diseases, researchers compared two methods of half-life estimation to evaluate the half-life of maternal antibodies present in infants against pertussis induced by tetanus, diphtheria, acellular pertussis vaccine administered to mothers during pregnancy.
However, these estimates are believed to be an underestimation, and studies show that the true burden of pertussis in infants is close to five million, with close to 86,000 deaths among infants below the age of one. The vaccination regimen for the infant can then be decided based on how long the maternal antibodies persist in the infant's immune system.
Furthermore, while both studies included pregnant women who had been administered the Tdap vaccine between six and eight months of gestational age, the Belgian cohort included both pre-term and term infants, while the Thai cohort only included infants born after eight months of gestation. Two approaches — direct and indirect — were used to estimate the half-life of the antibodies against each of the three antigens. The direct method assumed a constant decay rate, while the indirect method used a linear mixed-effect model to estimate the decay rate.
The half-life estimates also differed between the antibodies against the three pertussis-specific antibodies.
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