Study reveals type 2 diabetes diagnosis spurs cholesterol shifts, alters Ccardiovascular risk Type2Diabetes Cholesterol CVDRisk CardiovascularDisease Health Research Diabetes SciReports
CVD is the global leading cause of mortality. T2D is a gateway disease to CVD. A study revealed higher coronary heart disease and stroke risks in diabetes patients than in non-diabetic individuals. The global prevalence of T2D is expected to exceed 10% by 2030. Therefore, preventing CVD in people with diabetes could be of public health significance.
About the study In the present study, researchers explored the relationship between the change in TC levels pre- and post-T2D diagnosis with the risk of CVD. They selected participants with T2D from 2003 to 2012 from the National Health Insurance Service - Health Screening cohort in Korea. Patients were identified using relevant International Classification of Diseases, Tenth Revision codes and based on the prescription history of anti-diabetes drugs.
Findings The study included 23,821 participants; 9.9% were diagnosed with CVD. The incidence of CHD and stroke was 4.9% and 5.1%, respectively. Patients with increased TC levels after T2D diagnosis were likely to have higher use of lipid-lowering drugs, body mass index , fasting serum glucose, blood pressure, aspartate transaminase, alanine transaminase, and lower physical activity compared to those who had constant or unchanged TC levels post-T2D diagnosis.
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