Schizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, especially challenging.
May 24 2024McLean Hospital In a new study, published May 23 is Science, a team led by McLean Hospital researchers used comprehensive genetic and cellular analyses to shed new light on the intricate molecular mechanisms underlying schizophrenia. Their new work provides a map for how the genes known to increase risk of schizophrenia affect specific cells within the brain.
W. Brad Ruzicka MD, PhD, lead and co-corresponding author, director of the Laboratory for Epigenomics in Human Psychopathology at McLean Hospital For the new study, a multi-center team of researchers conducted a comprehensive single-cell analysis of transcriptomic changes in human prefrontal cortex, examining postmortem brain tissue from 140 individuals across two independent cohorts. Their analyses included more than 468,000 cells.
Related StoriesThe new study suggests potential links between schizophrenia pathology and processes such as neurodevelopment, synaptic signaling, and transcriptional regulation, implicating key transcriptional regulators associated with both schizophrenia and neurodevelopmental disorders.
Genetic Schizophrenia Brain Epigenomics Genes Hospital Laboratory Medical School Mental Health Research Transcription Transcription Factors
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study links organization of neurotypical brains to genes involved in autism and schizophreniaThe organization of the human brain develops over time, following the coordinated expression of thousands of genes. Linking the development of healthy brain organization to genes involved in mental health conditions such as autism and schizophrenia could help to reveal the biological causes of these disorders.
Read more »
Study uncovers cell type-specific genetic insights underlying schizophreniaSchizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, especially challenging.
Read more »
Dad forgives son who stabbed mum to death 11 times after a row over moneyBradley Huggins was suffering from schizophrenia at the time.
Read more »
Dad forgives son who stabbed mum to death 11 times after a row over moneyBradley Huggins was suffering from schizophrenia at the time.
Read more »
Plymouth man stabbed 'cherished' mother to death while suffering from schizophreniaAfter the killing, Huggins phoned police and then confessed to his father.
Read more »
Macaque study sheds light on brain's perception of static imagesWe may not realize it, but our eyes constantly make rapid movements—two to three per second—even when we're looking at the same spot. Yet despite these frequent eye movements, we still perceive what we see as a stable whole.
Read more »