Study shows Alzheimer’s disease-associated retinopathy can be ameliorated by dietary lysophosphatidylcholine-EPA/DHA UofIllinois Alzheimers Alzheimersdisease disease retinopathy
By Pooja Toshniwal PahariaJun 8 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Scientific Reports, researchers evaluated the impact of dietary lysophosphatidylcholine , comprising eicosapentaenoic acid and docosahexaenoic acid , on retinal function in Alzheimer’s disease -associated retinopathy.
About the study In the present study, researchers investigated whether increasing retinal DHA levels by supplementing diets with LPC-DHA could improve AD-related retinopathy among 5XFAD murine animals. Results 5XFAD mice demonstrated retinal DHA in significantly lower amounts than the wild-type mice, and LPC supplementation rapidly normalized the levels of docosahexaenoic acid and increased those of retinal eicosapentaenoic acid by severalfold. In contrast, comparable quantities of EPA and DHA as TAG modestly impacted retinal EPA and DHA.
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