Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone biorxivpreprint UniofOxford LSTMnews ljiresearch immunity SARSCoV2 vaccination vaccine covid
By Pooja Toshniwal PahariaJan 30 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the bioRxiv* preprint server, researchers characterized immunological responses by pulmonary mucosal tissues post-coronavirus disease 2019 vaccination and/or severe acute respiratory syndrome coronavirus 2 infection, to assess the impact of hybrid immune protection on the durability of mucosal immunological responses.
About the study In the present study, researchers assessed the potential of peripheral COVID-19 vaccinations to elicit anti-SARS-CoV-2 immunological memory in human pulmonary mucosal tissues and investigated whether prior COVID-19 history influenced the immune outcomes. Results The team observed humoral and cell-mediated immunity with enriched anti-spike protein titers, class-switched memory B lymphocytes, and T lymphocytes in pulmonary mucosal tissues than the peripheral titers in the background of hybrid immune responses. On the contrary, concerning COVID-19 vaccinations only, local-level anti-SARS-CoV-2 immune responses were restricted to humoral responses. Anti-S T lymphocytes were persistent in pulmonary mucosal tissues for ≤5.
Pulmonary anti-spike and anti-receptor-binding domain immunoglobulin G titers were eight-fold and nine-fold greater among individuals with hybrid immunity compared to the SARS-CoV-2-naïve vaccinees, respectively. Compared to control individuals, SARS-CoV-2-infected COVID-19 vaccinees showed three-fold higher mucosal IgA titers against the spike protein and higher greater IgA titers against SARS-CoV-2 RBD.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study evaluates SARS-CoV-2-specific antibody response in human milkIn a recent study published in the journal Communications Biology, researchers investigated the effect of the coronavirus disease 2019 (COVID-19) vaccine booster on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the milk of lactating women. Additionally, they explored whether the booster-induced antibody response differed from the homologous and heterologous boosting schedule of their primary vaccination.
Read more »
Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccinationPregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination Coronavirus Disease COVID Pregnancy mRNA Vaccine AJOG_thegray WeillCornell
Read more »
Children's tonsils are major sites of prolonged SARS-CoV-2 infectionChildren's tonsils are major sites of prolonged SARS-CoV-2 infection ChildHealth Tonsils adenoids Children Coronavirus Disease COVID SARSCoV2 medrxivpreprint Unesp_Global
Read more »
Endangered shark meat sold in Australian fish and chip shops, study findsResearchers from the University of Adelaide found meat from four threatened species, including the shortfin mako shark and smooth hammerhead, being sold as 'flake' in some takeaways in South Australia.
Read more »
China stops recognizing online study, orders return to classPLUS: NTT’s haptics advance; Australia cracks down on influencers; Korean Uni websites hit by Chinese protestors; and more
Read more »
Research supports weight-neutral care for women with binge eating disordersIn a recent study published in the journal eClinical Medicine, researchers in the United States reported findings of qualitative research that they pursued to understand the perceived impact of weight stigma and weight-neutral care among women receiving treatment for binge eating disorder (BED) with type 2 diabetes. BED is the most common eating disorder in the United States (US).
Read more »