T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine

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T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma - Nature Medicine
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Clonally diverse and activated memory CD4+ Tcells at baseline are associated with the development of severe irAEs in patients with melanoma treated with immune checkpoint inhibitors immunotherapy toxicity AaronNewmanLab aadel_chaudhuri ax_lozano

We thank the patients and families involved in this study. We thank A. Nassar and L. Chen for technical assistance with the CyTOF experiments, including provision of resources, staining and processing of samples. We thank G. Ansstas and C. Kaufman for clinical samples. We also thank T. Ley, S. Devarakonda and M. Tal for providing critical feedback on the manuscript.

Brandon E. Turner, Chloé B. Steen, Gunsagar S. Gulati, Milad R. Vahid, Farnaz Khameneh & Aaron M. NewmanChloé B. Steen & Aaron M. NewmanBogdan A. LucaDivision of Dermatology, Washington University School of Medicine, St.

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