Nature research paper: Targeting Xist with compounds that disrupt RNA structure and X inactivation
values: one-way ANOVA with respect to control cells. n = 150 colonies combined from 3 independent experiments., No obvious effect on day 3 female EB growth after 24 h X1 treatment., Quantitation of EB outgrowth at day 5 . The distance from EB center to edge of outgrowth was measured in 100 d3 or 30 d5 EBs combined from 3 independent experiments. Data presented as in panel ., Weaker effect of X16 on ♀-TST EB outgrowth. No obvious effect of X-negative.
Extended Data Fig. 5 Karyotype analysis of ES cells and RNA immunoFISH analysis of day 3 X1-treated cells., X-chromosome painting DNA FISH of DMSO- and X1-treated XX TST cells, and a DMSO-treated XO clone that spontaneously arose from the XX TST cells. Scale as shown. Inset: magnification of representative nucleus. %nuclei with indicated X chromosome number shown. n, sample size combining from 3 biologically independent experiments.
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