Telomeres, mitochondria, and inflammation: Three hallmarks of aging work together to prevent cancer salkinstitute nature
"We were excited to discover that telomeres talk to mitochondria," says Karlseder, holder of the Donald and Darlene Shiley Chair."They clearly synergize in well-controlled biological processes to initiate cellular pathways that killWhen telomeres shorten to a point where they can no longer protect chromosomes from damage, a process called"crisis" occurs and cells die.
In this study, the team wanted to know how autophagy-dependent cell-death programs are activated during crisis, when telomeres are extremely short. By conducting a genetic screen using human skin cells called fibroblasts, the scientists discovered interdependent immune sensing and inflammatory signaling pathways—similar to the ones by which thecombats viruses—that are crucial for cell death during crisis.
"Telomeres, mitochondria, and inflammation are three hallmarks of aging that are most often studied in isolation," says Shadel, holder of the Audrey Geisel Chair in Biomedical Science and director of the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging.
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