The formation of myelin during early development rests on an intricate balancing act in the phosphorylation of the protein cytohesin-2, according to a new scisignal study in mice.
Myelin sheaths protect and insulate neuronal axons, enabling more rapid neurotransmission. In the peripheral nervous system, myelin is made by Schwann cells. Miyamoto. found that myelin production by Schwann cells in mice was regulated by phosphorylation dynamics at an amino acid residue in the guanine nucleotide exchange factor cytohesin-2.
The guanine-nucleotide exchange factor cytohesin-2 activates the protein Arf6 to promote Schwann cell myelination. Here, we investigated the regulation of cytohesin-2 and found that the phosphorylation status of Tyrin cytohesin-2 is central to Schwann cell myelination. Knockin mice with a nonphosphorylatable Y381F mutation in cytohesin-2 exhibited reduced myelin thickness and decreased Arf6 activity in sciatic nerve tissue.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Made In’s New Dutch Oven Delivers Premium Performance at a Workaday PriceIt’s looks pretty good on the stovetop too.
Read more »
Custom Made Mouse Gives You the ‘Real’ Feeling of Firing a GunFrom mouse to gun, these coders have engineered the feeling of recoil. engineering
Read more »
Aston Martin boss: The V-12 isn't going anywhere soon, Valhalla in 2024, mid-engine Vanquish in 2025Aston Martin's keeping the V-12 alive until it's regulated out of existence.
Read more »
BingX Becomes Officially Regulated Exchange in United States and CanadaICYMI: after receiving licenses from U.S. and Canadian regulators, BingX can start operating as a legal exchange cryptoexchange cryptoregulation
Read more »
Genetically engineered immune cells have kept two people cancer-free for a decadeCancer doctors and researchers “don’t use words like ‘cure’ lightly or easily.” But with two patients remaining cancer-free for more than a decade, the therapy has performed “beyond our wildest expectations.”
Read more »
T cell responses to SARS-CoV-2 spike cross-recognize Omicron - NatureNature - T cell responses to SARS-CoV-2 spike cross-recognize Omicron
Read more »