The clinical and virological characteristics of severe neonatal echovirus 11 infections Eurosurveillanc francenews france publichealth virology virological neonate echovirus EV EV11 echovirus11
By Tarun Sai LomteJun 5 2023Reviewed by Lily Ramsey, LLM A recent study published in the Eurosurveillance Journal described severe and fatal infections in neonates caused by a new echovirus 11 variant in France.
Case description The nine cases, all males, from three metropolitan areas in France were admitted to pediatric intensive care for suspected sepsis. Patients showed hyperammonemia; three were treated with hemodialysis, five with sodium benzoate, and one succumbed before treatment initiation. Thrombocytopenia was observed in all patients; seven required plasma, platelets, and tranexamic acid.
The enteroviral genome was detected in all specimens, including cerebrospinal fluid, blood, stool, dried blood spots, post-mortem biopsies, and nasopharyngeal, throat, and rectal swabs. Next-generation sequencing identified E-11 as the causal agent in all cases. Molecular characterization and surveillance The researchers performed phylogenetic analyses of E-11 sequences from samples collected during 2010-23 in France and those from other countries available in the GenBank.
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