In a BugBitten blog post sophie_jm4 discusses the findings of a systematic review on the impact of mass drug administration on evolving resistance in malaria parasites.
The evolution of resistance to antimalarial drugs, taken from Moss et al., 2022.Antimalarial drug use on a mass scale In June 2022, the WHO released new guidelines for the treatment and prevention of malaria. These updated guidelines are less restrictive on drug use, suggesting that antimalarial drugs will be used more often on a ‘mass scale’. A summary of these changes can be found here.
How does DHA-PPQ work? Dihydroartemisinin-piperaquine is drug with two components: fast-acting dihydroartemisinin, and slow acting piperaquine. The fast-acting dihydroartemisinin has a short half-life and kills parasites quickly. This is paired with slow acting piperaquine, which ‘mops up’ by killing any parasites that are still remaining. The images below show how each of these components is hypothesised to work.
To supplement these therapeutic efficacy studies, researchers can monitor genomic changes in the parasite DNA, termed ‘molecular markers’. These markers are genomic mutations which have previously been associated with resistance to antimalarial drugs. Monitoring molecular markers is particularly useful on a population-based level. For example, blood samples or finger-prick dried blood spots can be sampled from people living in malaria endemic areas.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Spend the night in Disney World's secret Cinderella suite for free - here's howMICKEY Mouse is on the hunt for the UK’s biggest Disney fan – and you could spend the night in the exclusive Cinderella Suite at Disney World. The largest prize giveaway to date is in celebra…
Read more »
Kay Burley: The story behind our world exclusive interview with Ukraine's President ZelenskyyAs Kay Burley sat down for an exclusive interview with President Zelenskyy, he was told Germany would allow the export of Leopard 2 tanks to Ukraine. Here the Sky News presenter looks back at the build-up to that chat and how the extraordinary moment was caught on camera.
Read more »
Notts dancer is 'living the dream' touring the world with top artistsA dancer who has toured the world with top artists like Camilla Cabello, Ed Sheeran and KSI has shared what it's like to live the celebrity lifestyle.
Read more »
Fire Service - The Latest News from the UK and Around the World | Sky NewsAre fire services training up back-office staff during strikes? - KayBurley 'It takes years to become a competent firefighter and if this is happening - that is totally inadequate', says the Fire Brigades union's Matt Wrack KayBurley: 📺 Sky 501
Read more »
Preston Railway Station named one of the 'ugliest buildings in the world'It is also listed as third in the list of 'eyesore buildings in the UK'
Read more »