Inflammation is a core component of pain. But early inflammatory responses may protect against acute pain becoming chronic, according to an intriguing study of nearly 100 patients with low back pain.
of all chronic conditions in terms of years lived with disability, followed by headache disorders and depression.
In this study, Parisien and colleagues looked at gene expression levels in the immune cells of 98 patients with acute low back pain, comparing data from people whose pain resolved after three months with those from patients whose pain persisted. In other experiments, mice depleted of neutrophils took longer to resolve pain signals, while mice injected with neutrophils or the proteins neutrophils produce, did not develop long-lasting pain when treated with anti-inflammatory drugs.
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