The long-term effects of SARS-CoV-2 infection on T cell activation: autoimmune disorders and endothelial cell dysfunction FrontMedicine tcell thymuscell covid COVID19 SARSCoV2 autoimmune
By Vijay Kumar MalesuAug 1 2023Reviewed by Lily Ramsey, LLM In a recent review published in Frontiers in Medicine, a group of authors explored the impact of severe acute respiratory syndrome coronavirus 2 on thymus cell activation, autoimmune disorders, endothelial dysfunction, and vascular impairments.
SARS-CoV-2 infiltrates host cells via the angiotensin-converting enzyme 2 receptor, with variations in human genes influencing infection susceptibility and outcomes. Adrenal disease SARS-CoV-2 can impact adrenal function through various mechanisms, including hypothalamic–pituitary–adrenal axis dysfunction, direct cytopathic impact, immune-mediated inflammation, etc.Pancreas disorder Related StoriesSARS-CoV-2 can infect human pancreatic beta cells, inducing beta cell death similar to that detected in type 1 diabetes. Hyperglycemia is common in acute COVID-19 infections, even in patients who do not have diabetes.
Concerns regarding long-term spermatogenic failure and male infertility are still areas of uncertainty. Most studies have not reported the impact of COVID-19 on female fertility, but further studies are needed. The pathogenesis of AKI in acute COVID infection is multifactorial and includes activation of the immune system, endothelial injury, coagulation cascade, and the renin-angiotensin-aldosterone system.