There are three things to bear in mind when it comes to these new reports of suicidal thoughts in patients taking weight-loss drugs 🔎 Analysis by StuartJRitchie
drew a lot of attention for raising the possibility that GLP-1 agonists might improve people’s self-control and could help reduce addictive behaviours that aren’t related to food . However, there’sIn terms of effects on mood, the evidence is even more sparse. At least, from 2016, found that giving GLP-1 agonists to rats made them anxious at first, but this was balanced out by antidepressant effects in the longer term.
The very small-scale study induced the rat versions of anxiety and depression in the lab, such as seeing how they reacted to brightly-lit environments compared to darker ones . The relation of this to human anxiety and depression isn’t particularly clear. There are three things to bear in mind when it comes to these new reports of suicidal thoughts in patients taking GLP-1 agonists.
First, many thousands of diabetes patients have been taking Ozempic to help manage their condition for a long time – about, and longer if you count the patients in the trials before the medicine was approved for general use. There’s been little suggestion until now of any appreciable effects on mood – if this was a common side effect, it seems likely that it would have been noticed previously either in the trials or in everyday use of the drugs.
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