Glue inspired by barnacles could help surgeons save lives and time. (From 2021)
.) Then they tossed the sheets into a cryogenic grinder that pulverized them until they turned into shards roughly one hundredth of a millimeter across.
Yuk then compared the barnacle glue to products used by surgeons, sealant pastes like Surgiflo and a coagulation patch called TachoSil. In comparison, the barnacle glue formed a bond that was eight times tougher. And when tested on an isolated pig aorta for its “burst pressure”—the limit before a seal ruptures—Yuk’s glue held firm at up to twice the expected pressure from blood flow.
The barnacle-inspired glue is made from a mixture of sticky microparticles and silicone oil, which repels blood away from tissue.Then came the pigs. Yuk looped in a team at the Mayo Clinic that was better equipped to operate on large animals. The team wanted to avoid relying on the blood’s natural coagulation ability, since many people undergoing surgery have clotting issues themselves. So, before any experiments, the three test pigs received heparin, a blood thinner.
To be fair, coagulant patches like TachoSil aren't designed to stop heavy streams of blood from tissue with unclottable injuries. But, in medicine, that’s an unmet need, says Christoph Nabzdyk, a cardiac anesthesiologist and critical care physician on the Mayo team. “With aging populations, you have more and more patients that have either acquired bleeding disorders or are ultimately on blood thinners,” he says. “The problem of bleeding, and bleeding control is substantial.
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