New discoveries about embryonic blood stem cell creation made independently by biomedical engineers and medical researchers at the University of New South Wales (UNSW) Sydney could one day eliminate the need for blood stem cell donors. These achievements are part of a move in regenerative medicin
The microfluidic device that emulated an embryo’s heartbeat and blood circulation. The cell seeding channels are indicated by red food dye, while the heart ventricular contraction control channels and circulation valve control channels are indicated by blue and green food dye respectively. Credit: Jingjing Li, UNSW Sydney
UNSW researchers have recently completed two studies in this area that shine new light on not only how the precursors to blood stem cells occur in animals and humans, but how they may be induced artificially.by scientists from the UNSW School of Biomedical Engineering. They demonstrated how a simulation of an embryo’s beating heart using a microfluidic device in the lab led to the development of human blood stem cell ‘precursors’, which are stem cells on the verge of becoming blood stem cells.
“So we made a device mimicking the heart beating and the blood circulation and an orbital shaking system which causes shear stress – or friction – of the blood cells as they move through the device or around in a dish.” “Getting an aorta to form and then the cells actually emerging from that aorta into the circulation, that is the crucial step required for generating these cells.”
“Manufacture of blood stem cells from pluripotent stem cell lines would solve this problem without the need for tissue-matched donors providing a plentiful supply to treat blood cancers or genetic disease.”Mystery solved
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