Ticks found to harbor and release prions of chronic wasting disease SciReports ticks prions chronicwastingdisease CWD harbor release health research
By Pooja Toshniwal PahariaMay 17 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports Journal, researchers combined experimental tick feeding with tick evaluations from wild white-tailed deer to determine whether ticks may contain transmission-relevant amounts of chronic wasting disease -associated prions .
About the study The present study investigated whether ticks harbor and excrete CWD prions and contribute to their indirect transmission. The researchers evaluated whether they could retrieve and identify CWD-associated prions from the spiked blood and tick homogenates as opposed to the CWD-infected tissue or the brain, i.e., the source tissue and whether the rates of recovery varied depending on the sample type .
Further, the team investigated whether the status of CWD could be determined using simpler to obtain tissues , which might offer support for less intrusive antemortem chronic wasting disease testing. The RT-QuIC and PCMA assay results showed seeding activity in 40% of pooled tick samples, which were obtained from Odocoileus virginianus infected with CWD. The findings indicated a 7.0% to 40% CWD prevalence in Ixodes scapularis that had fed on CWD-infected white-tailed deer.
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